细胞自噬与肿瘤新辅助化疗关系的研究进展.PDF

中华普通外科学文献 （电子版） 2017 年 月第 卷第 期 （ ） 8 11 4 Chin Arch Gen Surg Electronic Edition , August 2017, Vol. 11, No.4 • • 273 ·综述 · 细胞自噬与肿瘤新辅助化疗关系的研究 进展 毛旭南  徐玉彬  张培建 【摘要】新辅助化疗是近年来治疗中期肿瘤的一种常用辅助方法，对缩小肿瘤的体积和杀死 已经部分转移的癌细胞具有显著的作用，能够为肿瘤的局部治疗提供良好的操作和根治基础。细胞 自噬是细胞程序性死亡的方式之一，在维持细胞正常生命代谢活动中起到至关重要的作用。自噬作 用在肿瘤细胞中依然存在，其对肿瘤细胞生长起到促进作用还是抑制作用目前仍然存在争议。新辅 助化疗对肿瘤细胞的自噬水平产生影响，自噬相关蛋白表达差异可以评价其对新辅助化疗的敏感性 和疗效，并有助于肿瘤新辅助化疗的适应证、药物选择。 【关键词】自噬；化学疗法, 辅助；肿瘤细胞 Progress of relationship between autophagy and tumor neoadjuvant chemotherapy Mao Xunan, Xu Yubin, Zhang Peijian. Institute of General Surgical Research, the Affiliated Hospital, Yangzhou University, Yangzhou 225000, China Corresponding author: Zhang Peijian, Email:@163.com Abstract 【 】 Neoadjuvant chemotherapy is commonly used to treat middle staged tumors in recent years, reducing the volume of tumor and killing metastasis cancer cells, and providing the basis for local treatment of tumor. Cell autophagy is one of the ways of programmed cell death, playing an important role in maintaining normal cellular metabolic activities. Autophagy exists in cancer cells, and it is still controversial of the effects of promotion or inhibition on tumor cells. Neoadjuvant chemotherapy has an influence on autophagy level in tumor cells, and the difference of autophagy related protein expression can be used to evaluate the sensitivity and efficacy of neoadjuvant chemotherapy, and it is helpful for the indication and drug selection of neoadjuvant chemother