高原和平原肾病综合症患者凝血纤溶系统改变的-第三军医大学学报.DOC

高原和平原肾病综合症患者凝血功能指标的对比分析 侯卫平1*，邓永明2，吴银平1，李少勇2，袁发焕1 (1.第三军医大学新桥医院肾内科〈全军肾脏病中心重庆市肾病研究所〉，重庆　400037; 2. 西藏军区总医院泌尿科，850007) 提要　目的：探讨高原和平原原发性NS患者凝血功能指标的差异，为高原NS患者的诊治提供参考依据。方法：(高原组，n=0)和重庆新桥医院肾内科(平原组，n=0) NS患者凝血酶原(P)、活化部分凝血活酶时(APTT)、纤维蛋白原(F)、D-二聚体(D-D)和血浆抗凝血酶Ⅲ（AT-Ⅲ）活性：Fib和D-D显著增高（P0.01），AT-Ⅲ活性显著降低（P0.01）。两组NS患者间相比，高原NS患者的Fib和D-D均显著高于平原NS组（P0.01）, 而AT-Ⅲ活性明显低于平原NS组（P0.01）。结论: 高原NS患者凝较强。 ；Comparison of hypercoagulable state related indexes in patients with nephrotic syndrome at high altitude and in plain area HOU Wei-ping1, DENG Yong-ming2, WU Yin-ping1, LI Shao-yong2, YUAN Fa-huan1* （1．Center for Renal Disease Research, Department of Nephrology, Xinqiao Hospital,Third Military Medical University, TCngqing, 400037, China; 2.Department of Urology, General Hospital of Tibetan Military Command, Lhasa,Tibet, 850007, China.） Abstract Objective：To investigate the difference of hypercoagulable state of the patients with nephrotic syndrome between at high altitude and in plain area so as to help the diagnosis and treatment of this disease at high altitude. MethodsIt was detected simultaneously the levels of prothrombin time(PT)，activated partial thromboplestime (APTT)， fibrinogen(Fib)， antithrombin-Ⅲ(AT-Ⅲ) and D-dimer of nephrotic syndrome patients from the General Hospital of Tibetan Military Command (above sea level 3680m, high altitude group, n=30) and Xinqiao Hospital (above sea level 300 m, plain group, n=30) and normal control (n=30)，respectively. The detected results from three groups were compared each other. Results：There was no significantly differences in PT and APTT between three groups (P0.05)，and the levels of Fib and D-dimer were obviously higher but AT-Ⅲ was obviously lower in two NS groups than those in normal control group (p0.01). Compared two groups of nephrotic syndrome, the level of Fib and D-dimer was higher，but AT-Ⅲ was lower significantly in high altitude group than those of the plain group(p0.01). Conclusion：The activity of coagulation in nephrotic synd