长期服用抗精神病药慢性精神分裂症患者血清S100B蛋白浓度变化.docVIP

长期服用抗精神病药慢性精神分裂症患者血清S100B蛋白浓度变化【摘 要】目的:探讨血清S100B蛋白浓度在长期服用抗精神病药慢性精神分裂症患者中的变化及与精神病理症状间的关系。方法:采用酶联免疫(ELISA)方法,检测99例长期服用抗精神病药治疗的慢性精神分裂症患者(精神分裂症组)和83名健康对照(对照组)血清S100B蛋白浓度,比较2组间差异。采用阳性和阴性症状量表(Positive and Negative Syndrome Scale ,PANSS)评定精神病理症状,分析血清S100B蛋白浓度与PANSS评分及其疾病状况间的关系。结果:①精神分裂症组血清S100B浓度高于对照组[(0.158±0.037)μg/L vs.(0.124±0.055)μg/L,P0.001];精神分裂症组中,男性患者S100B 水平高于女性[(0.169±0.035)μg/L vs.(0.136±0.030)μg/L,P0.001],采用典型抗精神病药、非典型抗精神病药、氯氮平和联合治疗4个亚组间差异无统计学意义(F=1.22,P=0.307);②精神分裂症患者血清S100B浓度与PANSS阴性症状分(r=-0.31,P=0.002)、反应缺乏因子(r=-0.24,P=0.017)负相关。结论:血清S100B水平在慢性精神分裂症患者中显著升高;S100B对疾病的进程可能有一定的保护作用。 【关键词】 精神分裂症;S100B蛋白;抗精神病药物;病例对照研究 中图分类号:R749.3,R749.053 文献标识码:A 文章编号:1000-6729(2010)004-0261-04 doi:10.3969/j.issn.1000-6729.2010.04.005 Increased serum S100B protein in long-term antipsychotic medication chronic patients with schizophrenia TAN Yun-Long?1,TAN Shu-Ping?1,CHEN Nan?1,HAN Biao?1,YANG Fu-De?1,CAO Lian-Yuan?1, LI Jia?1,ZHOU Dong-Feng2,ZOU Yi-Zhuang1 ?1Psychiatry Research Center,Beijing Huilongguan Hospital,Beijing 100096,China. ?2 Institute of Mental Health,Peking University,Key Laboratory of Mental Health,Ministry of Health (Peking University),Beijing 100191,China Corresponding author, ZHOU Dong-Feng,E-mail:zhoudf@bjmu.省略;ZOU Yi-Zhuang,E-mail:yzouy@263.net 【Abstract】 Objective:To investigate the correlation of the serum S100B protein levels with psychopathological symptoms in the long-term antipsychotic-medication chronic patients with schizophrenia.Methods:The serum S100B protein levels in 99 cases of the long-term antipsychotic-medication patients with chronic schizophrenia(schizophrenic group)and 83 healthy volunteers(control group)were examined by enzyme-linked immuno-sorbent assay(ELSIA).The serum S100B levels were compared between the schizophrenics and controls.Psychopathological symptoms were assessed with the Positive and Negative Symptom Scale(PANSS).The relationship of the serum S100B levels and the PANSS scores were analyz