双环醇治疗乙肝病毒再激活后肝功能异常疗效观察.docVIP

双环醇治疗乙肝病毒再激活后肝功能异常疗效观察[摘要] 目的 观察双环醇治疗乙型肝炎病毒（HBV）再激活后肝功能异常的疗效。 方法 将结核病合并乙型肝炎患者因抗结核治疗而发生乙肝病毒再激活病例60例，随机分为治疗组（30例）和对照组（30例）。两组患者均停用抗结核药，并给予拉米夫定抗病毒及一般保肝药物治疗。在此基础上，治疗组给予双环醇50 mg，每天3次，口服。治疗2个周、4个周后复查肝功。观察两组患者肝功恢复情况。 结果 治疗2个周及4个周后ALT下降幅度及复常率，治疗组均优于对照组（P ＜ 0.01），未见明显药物不良反应。 结论 双环醇对治疗乙肝病毒再激活后肝功能异常，起到了比较理想的保肝、降酶作用，疗效显著。 [关键词] 双环醇；HBV再激活；乙型肝炎；结核病 [中图分类号] R575.2 [文献标识码] A [文章编号] 1673-7210（2012）07（b）-0056-02 Observation on the effects of Bicyclol in treating abnormal liver function because of hepatitis B virus reactivation WEI Maozhou ZHENG Rong Department of Gastroenterology, the Second People’s Hospital of Weifang City, Shandong Province, Weifang 261041, China [Abstract] Objective To observe the effects of Bicyclol in treating abnormal liver function because of hepatitis B virus (HBV) reactivation. Methods 60 tuberculosis paients with HBV infection who happened HBV reactivation were divided into the treatment group (30 cases) and control group (30 cases) according to the order of being in hospital. In addition to stop antitubercular treatment, both groups recevived Lamivudine and general medicine to protect liver. In addition, the treatment group recevived Bicyclol, 50 mg once, 3 times a day，per os. 2 weeks and 4 weeks after treatment, liver function was checked to observe the effects and ALT descent level and recovery rate of ALT. Results 2 weeks and 4 weeks after treatment, the decrease amplitude of ALT and normalization rate of the treatment group were significantly better than the control group (P ＜ 0.01). There were no obvious adverse reactions of the two groups. Conclusion The effects of Bicyclol in treating abnormal liver function because of HBV reactivation is remarkable and Bicyclol has more ideal action to protect liver and fall enzyme. [Key words] Bicyclol; HBV reactivation; Hepatitis B; Tuberculosis 在我国，人群乙型肝炎病毒（HBV）表面抗原携带率为9.72%[1]。这些HBV感染者或携带者在接受细胞毒性化疗或免疫抑制剂治疗时，容易出现HBV再激活，表现为HBV-DNA水平较前升高或阳转，伴有或不伴有肝功异常，直接影响原发病的治疗。2009年2月～2011年6月笔者用双环醇治疗HBV再激活后肝功能异常3