_丹参酮ⅡA药理作用的研究进展_丹参酮ⅡA药理作用的研究进展.pdfVIP

2010 9 16 17M edicalR ecapitulate, Sep 2010, V o.l 16, No. 17 2661 A 1, 2 1 2 () , , ( ) 张萌涛 钱亦华 唐安琪 ( 1. , , , 710061; 2. , 710061) : R96 : A :( 2010) : 丹参酮A 具有多种药理作用, 能对抗心肌急性缺氧损伤抗心律失常改善血管平 1. 1 滑肌 能, 对缺血/再灌注引起的组织损伤具有保护作用丹参酮A 通过对肿瘤细胞的杀伤 [ 3] A 诱导分化和凋亡抑制侵袭和转移的机制发挥抗肿瘤作用丹参酮A 还具有神经保护作用, 将对神经系统疾病防治有重要意义 , : 丹参酮A; 心血管作用; 抗肿瘤; 神经保护; 清除氧自由基 A Research Progress ofPharmacologicActions ofTanshinoneA ZHAN G M engtao 1, 2, QIAN Yi , 1 2 hua , TANG A nq i . ( 1. D ep artm ent of H um an A na tom y and H isto ogy Em bry o ogy, R esearch Institute of , , N eurobio ogy, K ey Labora tory of E nvironm en t and G enes R e ated to D isea ses of S ta te M in istry of Educa ht tion, X ian J iaotong Universi ty C o ege of M ed icine, X ian 710061, Ch ina; 2. The 7 Ward, X ian Che st M ed icine H osp ita , X ian 710061, C hina ) Abstract: The present findin s show th at Tansh inone A (T anA) have extensive pharmacolo i A cal effects. Tan A can counteract the dam a es indu ced by acute m yocardial hypox ia, in cludin ar rhythm ias. It mi proves the function of vascular smooth mu scles and protect for th e ischem ic /reperfused , tissues. TanA is capable of k illin tum or cells, inducin th e differentiation and apoptosis, and inh ib i tin the invasion and tran sm ission. T anA also h as additional neuroprotective effects, si n ificant for the , , treatm ent and protection of nervous system. Key words: Tan sh inon