中医辨证分型治疗对美多巴增效减毒的影响.pdfVIP

796 2007 9 27 9 CJIT WM, September 2007, Vol. 27, No. 9 连新福 雒晓东 观察中医辨证分型治疗对帕金森病患者使用美多巴的减毒 效作用 共选择帕金 森病患者 101例进行前瞻性分层随机试验, 其中强直少动型用帕病 1 号方加美多巴片( 帕病 1 号组, 22 例) 治疗, 震颤型用帕病3 号方加美多巴片( 帕病3 号组, 30 例) 治疗, 对照组采用中药协定方加美多巴片(49例) 治疗3 组均以3 个月为1 个疗程观察临床疗效及治疗前后帕金森病评定量表( U DRS 评分) , 并进行不 良反应监测 治疗后, 帕病3 号组U DRS 评分各项积分和总分均有明显改善( P 001) , 帕病 1 号 组对照组各项积分明显改善( P 001) , 帕病1 号组帕病3 号组的改善幅度优于对照组( P 001) ; 帕病 1 号组帕病3 号组对照组进步率分别为955% (21/ 22 例) 1000% ( 30/ 30 例) 和837% ( 45/ 49 例) , 帕 病1 号组帕病3 号组优于对照组, 差异有显著性( P 005) 帕病1 号组治疗前后并发症积分差值与对照 组比较, 差异有显著性( P 005) 中医辨证分型治疗帕金森病能够改善症状减少并发症, 对美多 巴有减毒 效的作用 帕病 1 号方; 帕病3 号方; 中西医结合治疗; 帕金森病; 减毒 效 Effect of TCM Treatment According to Syndrome Differentiation in Enhancing Curative Effect and Reducing Side-effect of Madopa LIAN Xin-fu and LUO Xiao-dong Guangdong Provincial H osp ital of Tr aditional Chi- nese Medicine, Guangdong (510120) Abstract Objective To observe the effect of TCM treatment according to syndrome differentiation in en- hancing curative effect and reducing side-effect of madopa in patients with arkinson s disease ( D) . Methods T he trial was conducted in 101 D patients with a prospective stratified randomized and controlled method. T hey were assigned to group 1 in which the patients of rigidity were treated with abing Recipe 1 ( R1) plus Madopa tablets, group 2 with those of tremor given abing Recipe 3 ( R3) plus Madopa tablets, and group 3 given a fixed Chinese recipe plus Madopa tablets as the control. The treatment course for all the groups was 3 months. Clinical efficacy was evaluated with unified arkinsons disease rating scale ( U DRS) and the adverse reactions observed before and after treatment. Results After treatment, the 4 partial scores and the total score of U DRS decreased significantly in group 2 (P 001) , and the former of them and the total score dec