mir-17–92isrequiredforcardiomyocyteproliferationinembryonic.ppt

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2017-08-19 发布于天津
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mir-17–92isrequiredforcardiomyocyteproliferationinembryonic.ppt

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mir-17–92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult HeartsNovelty and Significance by Jinghai Chen, Zhan-Peng Huang, Hee Young Seok, Jian Ding, Masaharu Kataoka, Zheng Zhang, Xiaoyun Hu, Gang Wang, Zhiqiang Lin, Si Wang, Willam T. Pu, Ronglih Liao, and Da-Zhi Wang Circulation Research Volume 112(12):1557-1566 June 7, 2013 Copyright ? American Heart Association, Inc. All rights reserved. miR-17–92 is required for cardiomyocyte proliferation in embryonic, postnatal, and adult hearts. Jinghai Chen et al. Circ Res. 2013;112:1557-1566 Copyright ? American Heart Association, Inc. All rights reserved. miR-17–92 induces cardiomyocyte proliferation in embryonic and postnatal hearts. Jinghai Chen et al. Circ Res. 2013;112:1557-1566 Copyright ? American Heart Association, Inc. All rights reserved. miR-17–92 induces cardiomyocyte proliferation in postnatal and adult hearts. Jinghai Chen et al. Circ Res. 2013;112:1557-1566 Copyright ? American Heart Association, Inc. All rights reserved. Control of cardiomyocyte proliferation by miR-17–92 in adult heart in response to myocardial infarction. Jinghai Chen et al. Circ Res. 2013;112:1557-1566 Copyright ? American Heart Association, Inc. All rights reserved. miR-17–92 regulates cardiomyocyte proliferation and represses the expression and function of phosphatase and tensin homolog (PTEN). Jinghai Chen et al. Circ Res. 2013;112:1557-1566 Copyright ? American Heart Association, Inc. All rights reserved. miR-17–92 is required for cardiomyocyte proliferation in embryonic, postnatal, and adult hearts. A, Hematoxylin and eosin staining of sagittal sections of hearts from 2-day-old, wild-type, heterozygote, and mutant miR-17–92 KO mice. Bar=1 mm. B, Immunohistochemistry of phosphorylated histone H3 (phospho-H3, pH3) on sagittal sections of hearts from 2-day-old, wild-type, heterozygote, and mutant miR-17–92 KO mice. Bar=100 μm. C, Immunohistochemistry of sagittal sections of hear