奥沙利铂联合5-FU／LV与伊利替康联合5-FU／LV比较治疗晚期结直肠癌的系统评价.pdfVIP

奥沙利铂联合5一FU／LV与伊利替康联合5一FU／LV 比较治疗晚期结直肠癌的系统评价 王 艇1 罗黎力2周清华3 吴泰相 1．四川大学华西医院肿瘤中心 (成~610041)；2．四川大学华西妇女儿童医院；3．四川大学华西医院，天津医科大学总医院，天 津市肺癌研究所；4．四川大学华西医院中国循证医学中心临床流行病学教研室 摘要 目的 比较伊利替康联合5-FU／LV方案(IRI+5．FU／LV)与奥沙利铂联合5-FU／LV方案(OXA+5．FU／ Lv)治疗晚期结直肠癌的临床疗效和安全性。方法 计算机检索Cochrane图书馆临床对照试验资料库(2007年 第2期)、MEDLINE(1966～2007)、EMbase(1984～2004)、CBMdic(1978～2007)、CNKI(1994～2007)及 相关会议论文集及药厂资料，纳入随机对照试验及半随机对照试验，采用Cochrane系统评价方法进行评价。结 果 共纳入7个研究2 107例患者，OXA+5．FU／LV方案显示出相对优于或等于IRI+5．FU／LV方案的中位生存期 和疾病进展时间，OXA+5．FU／LV方案显示出相对较高的有效率和较低的毒副作用。结论 晚期结直肠癌治疗中 OXA+5一FU／LV方案比IRI+5．Fu／LV方案更适合患者。 关键词 结直肠癌；化学17厶疗；伊利替康；奥沙利铂；系统评价；Meta分析 Irinotecan versus Oxaplatin in Combination with 5一FU／I for Advanced Colorectal Cancer：A Systematic Review WANG Ting’，LUO Li-li ，ZHOU Qing-hua。，WU 1_ai-xiang 1．Tumor Center ofWest China Hospital,Sichuan Universi} Chengdu 610041，China； 2．The Second West China Hospital ofSichuan University,Chengdu 610041，China； 3．West China Hospital，Sichuan University,Chengdu 610041，China；Tia in Lung Cancer Institut~Tianj in Medical University General Hospital,Tia in 300052,China 4．Chinese Evidence—basedMedicine Center,West China Hospital,Sichuan Universi Chengdu 610041，China Abstract 0bjective To compare and evaluate the effectiveness and safety of irinotecan(IRI)versus oxaplatin (OXA)，in combination with 5-FU／LV for patients with advanced colorectal cancer．Methods The literature search， study selection and assessment，data collection and analysis were undertaken by two reviewers according to the Cochrane Handbook for Systematic Reviews of Interventions．Randomised controlled trials(RCTs)or quasi—RCTs comparing IRI versus OXA，in combination with 5-FU／LV in the treatment of advanced colorectal cancer were collected．Results Seven studies involving 2 107 patients were included．The OXA／5一FU／LV regimen was superior or at least equal to the IRI／5一 FU／LV regimen in prolonging overall survival and time to progression．The OXA／5一FU／LV regimen showed a hig