从2型糖尿病的发病机制谈糖尿病治疗的新策略.pdfVIP

: ( ) 2008 2 29 2 351 从2 型糖尿病的发病机制 谈糖尿病治疗的新策略 * 刘佩文 余学锋 : 2 型糖尿病的发病机制主要为胰岛素抵抗与胰岛细胞分泌功能受损, 者相互依存相 互作用2 型糖尿病的治疗应以减轻胰岛素的抵抗和保护胰岛细胞为主, 以生活方式干预加 甲双胍作为基础治疗, 根据不同 个体在不同阶段所侧重的不同发病机制, 采用联合综合管 理 : 2 型糖尿病, 发病机制, 胰岛素抵抗, 药物, 治疗 : R587. 1 :A : 1002- 0772( 2008) 2- 0010- 05 New Strategies for Treatment of Type 2 Diabetes Based on Pathogenesis of the Disease L I U P ei wen, Y U X uef eng . Div ision of End ocrinology , X inhua H osp ital , Wuhan, H u ei Prov ince 430015, China Abstract: The pat hogenesis of type 2 iabetes is mainly involve in insulin resistance an impaire insulin secretion by cells, both of which interact w ith each others an promote the progress of iabetes. The treatment of type 2 iabet es shoul focus on relieving the insulin resist ance an prot ecting cell funct ion. Life style intervention plus metformin are essential treat ment for type 2 iabetes. T herapeutic options of ifferent t reatment are base on ifferent stages of the isease an ifferent path ogenic factors mainly involve in in ivi ual iabetes. Rational regimen for iabetes treatment not only inclu es comprehen sive management of isease itself, but also inclu es management of con itions such as hypertension an hyperlipi emia. Key Words: type 2 iabetes, pathogenesis, insulin resist ance, me ications, treatment [ 3- 4] , [ 5- 6] ( )