原创力文档comparative kinetics of immune responses and changes in cellular sub-sets detected in colorectal cancer patients vaccinated with mva-5t4 (trovax) administered alongside two different chemotherapy regimens英文论文.pdfVIP
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comparative kinetics of immune responses and changes in cellular sub-sets detected in colorectal cancer patients vaccinated with mva-5t4 (trovax) administered alongside two different chemotherapy regimens英文论文
Journal of Cancer Therapy, 2011, 2, 54-64
doi:10.4236/jct.2011.21006 Published Online March 2011 (http://www.SciRP.org/journal/jct)
Comparative Kinetics of Immune Responses and
Changes in Cellular Sub-Sets Detected in
Colorectal Cancer Patients Vaccinated with
MVA-5T4 (TroVax) Administered Alongside Two
Different Chemotherapy Regimens
1 1 2 3 1
Michelle Kelleher , William Shingler , Robert E Hawkins , Alan Anthoney , Richard Harrop
1Oxford BioMedica (UK) Ltd., The Medawar Centre, Oxford Science Park, Oxford, UK; 2The Christie Hospital, Manchester, UK;
3St. James University Hospital, Leeds, UK.
Email: r.harrop@oxfordbiomedica.co.uk
Received January 26th, 2011; revised February 11th, 2011; accepted February 16th, 2011.
ABSTRACT
Modified vaccinia Ankara (MVA) virus encoding the tumor antigen 5T4 (MVA-5T4; TroVax ) has been tested in two
open-label phase II studies in metastatic colorectal cancer patients alongside two chemotherapy regimens, 5-fluorouracil,
folinic acid and irinotecan (IrMdG) or 5-fluorouracil, folinic acid and oxaliplatin (OxMdG). The aim of this study was
to investigate the kinetics of immune responses and changes in cellular sub-sets before, during and after treatment with
each chemotherapy regimen. In total, 23 patients received the complete course of treatment which comprised 2 injec-
tions before, during and after completion of chemotherapy. Antibody and cellular responses specific for 5T4 and MVA
were monitored throughout the study and changes in immune cell subsets were determined. All 23 evaluable patients
mounted MVA- and 5T4-specific cellular and/or humoral responses. Patients on both trials showed significant reduc-
tions in the numbers of neutrophils and the proportion of regul
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