enrichment discrimination behavior in spontaneously hypertensive rats浓缩在自发性高血压大鼠的歧视行为.pdfVIP

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enrichment discrimination behavior in spontaneously hypertensive rats浓缩在自发性高血压大鼠的歧视行为.pdf

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enrichment discrimination behavior in spontaneously hypertensive rats浓缩在自发性高血压大鼠的歧视行为

Journal of Behavioral and Brain Science, 2012, 2, 479-484 /10.4236/jbbs.2012.24056 Published Online November 2012 (http://www.SciRP.org/journal/jbbs) Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats Ramiz M. Salimov, Georgy I. Kovalev Laboratory of Radioisotope Researches, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia Email: rmsalimov@yandex.ru Received October 11, 2012; revised October 25, 2012; accepted October 31, 2012 ABSTRACT Objectives: 1) To reveal, among spontaneously hypertensive rats, subpopulations that diverge in attention to objects enriching an empty cross-maze; 2) To evaluate effect of clinically efficient drug for treatment of attention deficiency atomoxetine on the attention to environmental cues in attentionally-low rats. Method: A novel paradigm that provides measure of attention towards enriching objects independent of general locomotor activity and spatial orientation is em- ployed. The apparatus consists of 4-arm radial maze, two arms of which contain objects (enriched compartments). Animals exploring the objects typically stay longer in enriched parts of maze than in empty arms and have a higher score of enrichment discrimination ratio. Results: Frequency distribution of the enrichment discrimination ratio had clear bimodal shape that differed significantly from normal distribution suggesting the existence of subpopulations of attentionally-low and -high individuals. The attentionally-low phenotype did not show inferiority in spatial orientation as compared with attentionally-high phenotype. The phenotypes did not differ from each other in measures of locomo-