exact representations for tumour incidence for some density-dependent models确切表示肿瘤发病率密度依赖的模型.pdfVIP

EXACT REPRESENTATIONS FOR TUMOUR INCIDENCE FOR SOME DENSITY-DEPENDENT MODELS P. R. PARTHASARATHY AND KLAUS DIETZ Received 10 March 2005 Carcinogenesis is a multistage random process involving generic changes and stochastic proliferation and differentiation of normal cells and genetically altered stem cells. In this paper, we present the probability of time to tumour onset for a carcinogenesis model wherein the cells grow according to a birth and death process with density-dependent birth and death rates. This is achieved by transforming the underlying system of differ- ence equations w