angelicae dahuricae radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in ncnga mice中药白芷基数抑制尘螨extract-induced过敏性dermatitis-like ncnga老鼠的皮肤损伤.pdfVIP

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angelicae dahuricae radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in ncnga mice中药白芷基数抑制尘螨extract-induced过敏性dermatitis-like ncnga老鼠的皮肤损伤.pdf

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angelicae dahuricae radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in ncnga mice中药白芷基数抑制尘螨extract-induced过敏性dermatitis-like ncnga老鼠的皮肤损伤

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 743075, 7 pages doi:10.1155/2012/743075 Research Article Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice Hoyoung Lee, Jun Kyoung Lee, Hyekyung Ha, Mee-Young Lee, Chang-Seob Seo, and Hyeun Kyoo Shin Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, 483 Expo-ro, Daejeon Yuseong-gu, 305-811, Republic of Korea Correspondence should be addressed to Hyeun Kyoo Shin, hkshin@kiom.re.kr Received 8 July 2011; Revised 5 October 2011; Accepted 20 October 2011 Academic Editor: Yoshiyuki Kimura Copyright © 2012 Hoyoung Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We examined whether Angelicae Dahuricae Radix (AR) suppresses the development of atopic dermatitis (AD)-like skin lesions induced by Dermatophagoides farinae in NC/Nga mice. To investigate the eﬀect of AR, we measured the AD severity score, measured plasma levels of IgE and histamine, and performed histological analysis in NC/Nga mice. We also conﬁrmed the anti- inﬂammatory eﬀects of AR by measuring TARC/CCL17 production from LPS-treated RAW 264.7 cells and mRNA levels of TARC and MDC/CCL22 in TNF-α/IFN-γ-treated HaCaT cells. 10 mg/day of AR extract was applied for 4 weeks to NC/Nga mice. Both the AR extract and 0.1% tacrolimus suppressed the development of AD-like skin lesions and reduced dermatitis scores of the back and ear skin. AR extracts caused an inhibition of histological changes induced by repeated application of D. farinae and