angiotensin-converting enzyme genotype and peripheral arterial disease in diabetic patients血管紧张素转换酶基因型,在糖尿病患者外周动脉疾病.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 698695, 7 pages doi:10.1155/2012/698695 Research Article Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients Chin-Hsiao Tseng,1, 2 Farn-Hsuan Tseng,3 Choon-Khim Chong,4 Ching-Ping Tseng,5 and Ju-Chien Cheng6 1 Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan 3 Department of Biological Sciences, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, USA 4 Chong’s Physical Medicine and Rehabilitation Center, Taipei 116, Taiwan 5 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan 6 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan Correspondence should be addressed to Chin-Hsiao Tseng, ccktsh@ms6.hinet.net Received 31 May 2011; Revised 16 August 2011; Accepted 5 September 2011 Academic Editor: U. J. Eriksson Copyright © 2012 Chin-Hsiao Tseng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We investigated the effect of traditional risk factors (hypertension, dyslipidemia and smoking) on the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and peripheral arterial disease (PAD) in 945 (454 men and 491 women) Taiwanese type 2 d