brazilian green propolis inhibits inflammatory angiogenesis in a murine sponge model巴西绿蜂胶海绵抑制炎症性血管生成因子在鼠模型.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 182703, 7 pages doi:10.1093/ecam/nep197 Original Article Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model 1 ˆ 1 Sandra Aparecida Lima de Moura, Monica Alves Neves Diniz Ferreira, Silvia Passos Andrade,2 Maria Leticia Costa Reis,1 Maria de Lourdes Noviello,1 and Denise Carmona Cara1 1 Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil 2 Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil Correspondence should be addressed to Silvia Passos Andrade, andrades@icb.ufmg.br Received 11 May 2009; Accepted 31 October 2009 Copyright © 2011 Sandra Aparecida Lima de Moura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Angiogenesis and inflammation are persistent features of several pathological conditions. Propolis, a sticky material that honeybees collect from living plants, has been reported to have multiple biological effects including anti-inflammatory and anti-neoplasic activities. Here, we investigated the effects of water extract of green propolis (WEP) on angiogenesis, inflammatory cell accumulation and endogenous production of cytokines in sponge implants of mice over a 14-day period. Blood vessel formation as asses