原创力文档a comparative analysis of gene expression patterns and cell phenotypes between cervical and peripheral blood mononuclear cells比较分析的基因表达模式和颈和外周血单核细胞之间的细胞表型.pdfVIP
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a comparative analysis of gene expression patterns and cell phenotypes between cervical and peripheral blood mononuclear cells比较分析的基因表达模式和颈和外周血单核细胞之间的细胞表型
A Comparative Analysis of Gene Expression Patterns and
Cell Phenotypes between Cervical and Peripheral Blood
Mononuclear Cells
1.¤ 1. 1,2 3 4 `
Rachel E. Horton , Nadine Kaefer , Elijah Songok , Fernando B. Guijon , Nadia Kettaf , Genevieve
4 4 1,5 1,6
Boucher , Rafick-Pierre Sekaly , T. Blake Ball *, Frank A. Plummer
1 Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, 2 Kenya Medical Research Institute, Nairobi, Kenya, 3 Department of
´
Obstetrics, Gynaecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, 4 Centre de Recherche du Centre Hospitalier de l’Universite de
´ ´
Montreal, Montreal, Quebec, Canada, 5 National HIV and Retrovirology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, 6 National Microbiology
Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Abstract
Studies of the immunological environment in the female genital tract (FGT) are critical for the development of vaccines or
microbicides to halt the spread of sexually transmitted infections. Challenges arise due to the difficulties of sampling from
this site, and the majority of studies have been conducted utilising peripheral blood mononuclear cells. Identifying
functional differences between immune cells of the FGT and peripheral blood would aid in our understanding of mucosal
immunology. We compared t
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