原创力文档a kinome rnai screen identified ampk as promoting poxvirus entry through the control of actin dynamics激酶组rnai屏幕识别ampk促进痘病毒条目通过肌动蛋白动力学的控制.pdfVIP
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a kinome rnai screen identified ampk as promoting poxvirus entry through the control of actin dynamics激酶组rnai屏幕识别ampk促进痘病毒条目通过肌动蛋白动力学的控制
A Kinome RNAi Screen Identified AMPK as Promoting
Poxvirus Entry through the Control of Actin Dynamics
1 2 3 4 1
Theresa S. Moser , Russell G. Jones , Craig B. Thompson , Carolyn B. Coyne , Sara Cherry *
1 Department of Microbiology, Penn Genome Frontiers Institute, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America,
2 Goodman Cancer Center and Department of Physiology, McGill University, Montreal, Quebec, Canada, 3 Department of Cancer Biology, The University of Pennsylvania
School of Medicine, Philadelphia, Pennsylvania, United States of America, 4 Department of Microbiology and Molecular Genetics, The University of Pittsburgh, Pittsburgh,
Pennsylvania, United States of America
Abstract
Poxviruses include medically important human pathogens, yet little is known about the specific cellular factors essential for
their replication. To identify genes essential for poxvirus infection, we used high-throughput RNA interference to screen the
Drosophila kinome for factors required for vaccinia infection. We identified seven genes including the three subunits of
AMPK as promoting vaccinia infection. AMPK not only facilitated infection in insect cells, but also in mammalian cells.
Moreover, we found that AMPK is required for macropinocytosis, a major endocytic entry pathway for vaccinia.
Furthermore, we show that AMPK contributes to other virus-independent actin-dependent processes including lamellipodia
formation and wound healing, independent of the known AMPK activators LKB1 and CaMKK. Therefore, AMPK plays a highly
conserved role in poxvirus infection and actin dynamics independent of its role as an energy regulator.
Citation: Moser TS, Jon
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