a meta-analysis of interleukin-8 -251 promoter polymorphism associated with gastric cancer risk荟萃分析interleukin-8 -251启动子多态性与胃癌相关的风险.pdfVIP

A Meta-Analysis of Interleukin-8 -251 Promoter Polymorphism Associated with Gastric Cancer Risk 1 . 2. 3. 4. 4. 2 Huiping Xue * , Jianjun Liu , Bing Lin , Zheng Wang , Jianhua Sun , Gang Huang * 1 Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institution of Digestive Disease, Key Laboratory of Gastroenterology Hepatology, Ministry of Health, Shanghai Jiaotong University, Shanghai, People’s Republic of China, 2 Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China, 3 Division of Nutrition, Zhongshan Hospital, Fudan University School of Medicine, Fundan University, Shanghai, People’s Republic of China, 4 Department of General Surgery, Renji Hospital, Shanghai, People’s Republic of China Abstract Background: Potential functional allele A/T single nucleotide polymorphism (SNP) of Interleukin 8 (IL-8) promoter -251has been implicated in gastric cancer risk. Methods: We aimed to explore the role of A/T SNP of IL-8 -251 in the susceptibility to gastric cancer through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. Eighteen studies were ultimately eligible for the meta-analysis of IL-8 - 251 A/T SNP. We adopted the most probably appropriate genetic model (codominant model). Potential sources of heterogeneity were sought out via stratification and sensitivity analyses, and publication biases were estimated. Results: Between IL-8 -251 AA genotype with gastric cancer risk, statistic