SMOFlipid SMOFKabiven Project - Fresenius Kabi：smoflipid smofkabiven项目费森尤斯卡比.pptVIP

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SMOFlipid SMOFKabiven Project - Fresenius Kabi：smoflipid smofkabiven项目费森尤斯卡比.ppt

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SMOFlipid SMOFKabiven Project - Fresenius Kabi：smoflipid smofkabiven项目费森尤斯卡比

SMOFlipid: More than Energy in a TPN SMOFlipid SMOFlipid is a LE that provides … SMOFlipid is a LE that … SMOFlipid Clinical Evidence Controls serum Levels of TG Patients Treated with SMOFlipid presented controlled triglyceride levels with a tendency to lower increase Protects the Liver Function Beneficial Effects were observed in liver function of patients treated with SMOFlipid Immunomodulating Effects A positive effect on immuno response has been observed in patients treated with SMOFlipid Improve oxidative capacity α-tocopherol levels in plasma were maintained within the normal ranges in SMOFlipid group after 5 days of TPN Reports Clinical Benefits for the Patient Patients treated with SMOFlipid have shown a reduction on the Length of Hospital Stay Clinical Benefits for the Patient SMOFlipid … Background More about every single lipid emusion Source of essential Fatty Acids Soybean oil is a reliable source of the essential fatty acids: linoleic acid (ω-6 FA) and α-linolenic acid (ω-3 FA) MCT* Medium-Chain Triglycerides* (MCT) Capric acid Caproic acid … Rapidly available energy source Taken up into the mitochondria mainly in a carnitine independent pathway Lead to controlled triglyceride levels due to efficient elimination from the bloodstream Olive Oil Olive oil has High content in monoinsaturated fatty acid, oleic acid ω-9 Low content in saturated Low content ω6 fatty acids Olive oil doesn’t compete with de desaturation and elongation of α-linolenic acid Due to the benefits of olive oil observed as part of the Mediterranean diet, it’s one of the recommended fats in the diet. ω -3 Fatty Acids “Fish oil has the most favourable effects on survival, infection rates, length of stay in hospital and intensive care units and antibiotics demand in doses between 0.1 – 0.2 g/Kg/day”* Heller AR et al, Crit Care Med, 2006 ω-3:ω-6 Ratio Importance ω-3:ω-6 Ratio Importance What is the Optimal ω-3:ω-6 Ratio? Study Design Rat hearts were transplanted and treated with d