antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiographyα1-adrenergic受体抗体导致老鼠大脑血管损伤,磁共振血管造影.pdfVIP

Antibodies to the a -Adrenergic Receptor Cause Vascular 1 Impairments in Rat Brain as Demonstrated by Magnetic Resonance Angiography 1 2 2 3 1 Peter Karczewski *, Andreas Pohlmann , Babette Wagenhaus , Natali Wisbrun , Petra Hempel , 4 5 2,6 7 Bernd Lemke , Rudolf Kunze , Thoralf Niendorf , Marion Bimmler 1 E.R.D.E.-AAK-Diagnostik GmbH, Berlin, Germany, 2 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 3 Animal Facilities, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 4 IT Department, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 5 E.R.D.E. e.V., ´ ¨ Berlin, Germany, 6 Experimental and Clinical Research Center, a joint cooperation between the Charite Medical Faculty and the Max Delbruck Center for Molecular Medicine, Berlin, Germany, 7 Autoimmunity and G Protein-Coupled Receptors, Max Delbrueck Center for Molecular Medicine, Berlin, Germany Abstract Background: Circulating agonistic autoantibodies acting at G protein-coupled receptors have been associated with numerous sever pathologies in humans. Antibodies directed predominantly against the a1-adrenergig receptor were detected in patients suffering from widespread diseases such as hypertension and type 2 diabetes. Their deleterious action has been demonstrated for peripheral organs. We