原创力文档b cell depletion in hiv-1 subtype a infected ugandan adults relationship to cd4 t cell count, viral load and humoral immune responsesb细胞耗竭在hiv - 1亚型感染乌干达成人cd4 t细胞计数的关系,病毒载量和体液免疫反应.pdfVIP
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b cell depletion in hiv-1 subtype a infected ugandan adults relationship to cd4 t cell count, viral load and humoral immune responsesb细胞耗竭在hiv - 1亚型感染乌干达成人cd4 t细胞计数的关系,病毒载量和体液免疫反应
B Cell Depletion in HIV-1 Subtype A Infected Ugandan
Adults: Relationship to CD4 T Cell Count, Viral Load and
Humoral Immune Responses
1 1,2,3 2,3 2,3 1 2,3,4
Peter Oballah , Britta Flach , Leigh A. Eller , Michael A. Eller , Benson Ouma , Mark de Souza ,
Hannah N. Kibuuka1, Fred Wabwire-Mangen1,5, Bruce K. Brown2,3, Nelson L. Michael2,6, Merlin L.
2,3 7 2,6
Robb , David Montefiori , Victoria R. Polonis *
1 Makerere University Walter Reed Project, Kampala, Uganda, 2 Military HIV Research Program, Rockville, Maryland, United States of America, 3 The Henry M Jackson
Foundation, Rockville, Maryland, United States of America, 4 Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, 5 Makerere University School of
Public Health, Kampala, Uganda, 6 Walter Reed Army Institute of Research, Rockville, Maryland, United States of America, 7 Duke University, Durham, North Carolina,
United States of America
Abstract
To better understand the nature of B cell dysfunctions in subjects infected with HIV-1 subtype A, a rural cohort of 50
¨
treatment-naıve Ugandan patients chronically infected with HIV-1 subtype A was studied, and the relationship between B
cell depletion and HIV disease was assessed. B cell absolute counts were found to be significantly lower in HIV-1+ patients,
when compared to community matched negative controls (p,0.0001). HIV-1-infected patients displayed variable functional
and binding antibody titers that showed no correlation with viral load or CD4+ T cell count. However, B cell absolute counts
were found to correlate inversely w
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