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bitter taste receptors influence glucose homeostasis苦味受体影响葡萄糖体内平衡
Bitter Taste Receptors Influence Glucose Homeostasis
1 2 2 3 1 4
Cedrick D. Dotson , Lan Zhang , Hong Xu , Yu-Kyong Shin , Stephan Vigues , Sandra H. Ott ,
1 1 4 3 4
Amanda E. T. Elson , Hyun Jin Choi , Hillary Shaw , Josephine M. Egan , Braxton D. Mitchell , Xiaodong
2 4 1
Li , Nanette I. Steinle , Steven D. Munger *
1 Department of Anatomy Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Senomyx, Inc., San Diego,
California, United States of America, 3 National Institute on Aging/NIH, Baltimore, Maryland, United States of America, 4 Department of Medicine, Division of
Endocrinology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Abstract
TAS1R- and TAS2R-type taste receptors are expressed in the gustatory system, where they detect sweet- and bitter-tasting
stimuli, respectively. These receptors are also expressed in subsets of cells within the mammalian gastrointestinal tract,
where they mediate nutrient assimilation and endocrine responses. For example, sweeteners stimulate taste receptors on
the surface of gut enteroendocrine L cells to elicit an increase in intracellular Ca2+ and secretion of the incretin hormone
glucagon-like peptide-1 (GLP-1), an important modulator of insulin biosynthesis and secretion. Because of the importance
of taste receptors in the regulation of food intake and the alimentary responses to chemostimuli, we hypothesized that
differences in taste receptor efficacy may impact glucose homeost
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