原创力文档calpainshp-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nunu micecalpainshp-1交互努努和厚朴酚抑制胃癌腹膜传播的老鼠.pdfVIP
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calpainshp-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nunu micecalpainshp-1交互努努和厚朴酚抑制胃癌腹膜传播的老鼠
Calpain/SHP-1 Interaction by Honokiol Dampening
Peritoneal Dissemination of Gastric Cancer in nu/nu Mice
1. 2,9 3 4 4,9 9
Shing Hwa Liu , Keh Bin Wang , Keng Hsin Lan , Wen Jane Lee , Hung Chuan Pan , Sheng Mao Wu ,
5 9 6,7. 10 8
Yen Chun Peng , Yi Ching Chen , Chin Chang Shen , Hsu Chen Cheng , Ko Kaung Liao , Meei
Ling Sheu4,9*
1 Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, 2 Department of Nuclear Medicine, Kuang Tien General Hospital, Taichung,
Taiwan, 3 Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, 4 Department of Education and Research, Taichung
Veterans General Hospital, Taichung, Taiwan, 5 Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan,
6 Department of Chemistry, National Taiwan University, Taipei, Taiwan, 7 Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan, 8 Department of
Anatomy, Chung Shan Medical University, Taichung, Taiwan, 9 Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan, 10 Department of life
Sciences, National Chung Hsing University, Taichung, Taiwan
Abstract
Background: Honokiol, a small-molecular weight natural product, has previously been reported to activate apoptosis and
inhibit gastric tumorigenesis. Whether honokiol inhibits the angiogenesis and metastasis of gastric cancer cells remains
unknown.
Methodology/Principal Findings: We tested the effects o
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