can an infectious disease genomics project predict and prevent the next pandemic可以一个传染性疾病基因组学项目预测和预防下一次大流行.pdfVIP

Perspective Can an Infectious Disease Genomics Project Predict and Prevent the Next Pandemic? ¤ ¤ Rajesh Gupta *, Mark H. Michalski , Frank R. Rijsberman G, Mountain View, California, United States of America We believe that there is great potential influenza (commonly referred to as ‘‘swine N Sequencing and other molecular tech- in the systematic application of genomics, flu’’) [23–26]. nologies are everyday tools-of-the- proteomics, and bioinformatics to infec- To fully harness the benefit of genomics trade in every district hospital and tious diseases, and that this potential has in infectious diseases, a chain of overarch- laboratory in hotspots of emerging yet to be fully realized. We suggest that the ing activities must occur. First, under- infectious disease, such as southeast international community unite under an standing the dynamics of infectious diseas- Asia and sub-Saharan Africa. Infectious Disease Genomics Project, anal- es through the genomics lens requires a N Automated molecular diagnostic as- ogous to the Human Genome Project, tremendous amount of integrated com- says are low-cost, reduced at least to with a goal of a comprehensive, open- parative sequence, expression, epigenetic, the size of a smart mobile phone, and access system of genomic information to and proteomic data from a variety of can return definitive diagnoses of a accelerate scientific understanding and pathogens (bacteria, virus, protozoa, fun- range of sp