cd45rc isoform expression identifies functionally distinct t cell subsets differentially distributed between healthy individuals and aav patientscd45rc同种型表达式识别功能不同的t细胞健康个体之间不同子集分配和aav病人.pdfVIP

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cd45rc isoform expression identifies functionally distinct t cell subsets differentially distributed between healthy individuals and aav patientscd45rc同种型表达式识别功能不同的t细胞健康个体之间不同子集分配和aav病人.pdf

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cd45rc isoform expression identifies functionally distinct t cell subsets differentially distributed between healthy individuals and aav patientscd45rc同种型表达式识别功能不同的t细胞健康个体之间不同子集分配和aav病人

CD45RC Isoform Expression Identifies Functionally Distinct T Cell Subsets Differentially Distributed between Healthy Individuals and AAV Patients 1. 1. 1 2 Laurence Ordonez , Isabelle Bernard , Fatima-Ezzahra L’Faqihi-Olive , Jan Willem Cohen Tervaert , 2 1 Jan Damoiseaux , Abdelhadi Saoudi * ´ ´ ´ ´ ˆ ´ 1 Institut National de la Sante et de la Recherche Medicale (INSERM) U563, Institut Federatif de Recherche (IFR) 30, Hopital Purpan and Universite Paul Sabatier, Toulouse, France, 2 Department of Internal Medicine, Division Clinical and Experimental Immunology, Maastricht University Medical Centre, Maastricht, The Netherlands Abstract In animal models of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), the proportion of CD45RC T cell subsets is important for disease susceptibility. Their human counterparts are, however, functionally ill defined. In this report, we studied their distribution in healthy controls (HC), AAV patients and in Systemic lupus erythematous (SLE) patients as disease controls. We showed that CD45RC expression level on human CD4 and CD8 T cells identifies subsets that are highly variable among individuals. Interestingly, AAV patients exhibit an increased proportion of CD45RClow CD4 T cells as compared to HC and SLE patients. This increase is stable over time and independent of AAV subtype, ANCA specificity, disease duration, or number of relapses. We also analyzed the cytokine profile of purified CD4 and CD8 CD45RC T cell