co-deletion of chromosome 1p19q and idh12 mutation in glioma subsets of brain tumors in chinese patientsco-deletion染色体1 p19q idh12突变在中国患者脑部肿瘤的神经胶质瘤的子集.pdfVIP

Co-Deletion of Chromosome 1p/19q and IDH1/2 Mutation in Glioma Subsets of Brain Tumors in Chinese Patients 1 1 1 2 1 1 1 Xiaohui Ren , Xiangli Cui , Song Lin *, Junmei Wang , Zhongli Jiang , Dali Sui , Jing Li , Zhongcheng Wang2 1 Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China, 2 Beijing Neurosurgical Institute, Beijing, China Abstract Objective: To characterize co-deletion of chromosome 1p/19q and IDH1/2 mutation in Chinese brain tumor patients and to assess their associations with clinical features. Methods: In a series of 528 patients with gliomas, pathological and radiological materials were reviewed. Pathological constituents of tumor subsets, incidences of 1p/19q co-deletion and IDH1/2 mutation in gliomas by regions and sides in the brain were analyzed. Results: Overall, 1p and 19q was detected in 339 patients by FISH method while the sequence of IDH1/2 was determined in 280 patients. Gliomas of frontal, temporal and insular origin had significantly different pathological constituents of tumor subsets (P,0.001). Gliomas of frontal origin had significantly higher incidence of 1p/19q co-deletion (50.4%) and IDH1/2 mutation (73.5%) than those of non-frontal origin (27.0% and 48.5%, respectively) (P,0.001), while gliomas of temporal origin had significantly lower incidence of 1p/19q co-deletion (23.9%) and IDH1/2 mutation (41.7%) than those of non- temporal origin (39.9% and 63.2%, respectively) (P = 0.013 and P = 0.003, respectively). Subgroup analysis confirmed these findings in oligoastrocytic and oligodendroglial tumors, respectively. Although the difference of 1p/19q co-deletion was not statistically significant in temporal oligodendroglial tumors, the trend