differential expression of proteoglycans in tissue remodeling and lymphangiogenesis after experimental renal transplantation in rats差异表达的蛋白聚糖在组织重构和lymphangiogenesis实验性大鼠肾移植.pdfVIP

Differential Expression of Proteoglycans in Tissue Remodeling and Lymphangiogenesis after Experimental Renal Transplantation in Rats 1. 2. 3 4 2 Heleen Rienstra , Kirankumar Katta , Johanna W. A. M. Celie , Harry van Goor , Gerjan Navis , Jacob 2 4 van den Born , Jan-Luuk Hillebrands * 1 Immunology Section, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 2 Nephrology Division, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 3 Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 4 Pathology Division, Department of Pathology Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract Background: Chronic transplant dysfunction explains the majority of late renal allograft loss and is accompanied by extensive tissue remodeling leading to transplant vasculopathy, glomerulosclerosis and interstitial fibrosis. Matrix proteoglycans mediate cell-cell and cell-matrix interactions and play key roles in tissue remodeling. The aim of this study was to characterize differential heparan sulfate proteoglycan and chondroitin sulfate proteoglycan expression in transplant vasculopathy, glomerulosclerosis and interstitial fibrosis in renal allografts with chronic transplant dysfunction. Methods: Renal allografts were transplanted in the Dark Agouti-to-Wistar Furth rat strain combination. Dark Agouti-to-Dark Agouti isografts and non-transplanted Dark Agouti kidneys served a