dnmt3l modulates significant and distinct flanking sequence preference for dna methylation by dnmt3a and dnmt3b in vivodnmt3l调节重要和独特的旁侧序列偏好种能阻碍dnmt3b dnmt3a和体内的dna甲基化.pdfVIP

DNMT3L Modulates Significant and Distinct Flanking Sequence Preference for DNA Methylation by DNMT3A and DNMT3B In Vivo Bethany L. Wienholz, Michael S. Kareta, Amir H. Moarefi, Catherine A. Gordon, Paul A. Ginno, ´ ´ ´ Frederic Chedin* Department of Molecular and Cellular Biology, University of California Davis, Davis, California, United States of America Abstract The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using an in vivo episomal