dynamic prestress in a globular protein在球状蛋白质动态预应力.pdfVIP

Dynamic Prestress in a Globular Protein 1 1,2 ¨ 1,2 Scott A. Edwards , Johannes Wagner , Frauke Grater * 1 CAS-MPG Partner Institute and Key Laboratory for Computational Biology, Shanghai, China, 2 Heidelberg Institute for Theoretical Studies, Heidelberg, Germany Abstract A protein at equilibrium is commonly thought of as a fully relaxed structure, with the intra-molecular interactions showing fluctuations around their energy minimum. In contrast, h