endogenous nmnat2 is an essential survival factor for maintenance of healthy axons内源性nmnat2维护健康的轴突的生存是一个重要的因素.pdfVIP

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons Jonathan Gilley, Michael P. Coleman* The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom Abstract The molecular triggers for axon degeneration remain unknown. We identify endogenous Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde axonal transport is a limiting factor for axon survival. Specific depletion of Nmnat2 is sufficient to induce Wallerian-like degeneration of uninjured axons which