角化棘皮瘤恶变1例诊断体会（Diagnostic experience of 1 cases of malignant change of hyperkeratosis）.docVIP

角化棘皮瘤恶变1例诊断体会（Diagnostic experience of 1 cases of malignant change of hyperkeratosis） Diagnostic experience of 1 cases of malignant change of hyperkeratosis Update Date: 12-07 #e# Acanthosis is a benign lesion of the skin. Because oneself subsidise, can not do any treatment, also can choose an operation to undertake local excision, but very little case can have canceration, should cause clinical attention. Our hospital from August 2000 to August 2004, a total of 54 cases of pathological diagnosis of acanthosis, including 1 cases of malignant change of acanthosis, and this case is reported as follows, and analyzed. 1 Summary of patient history The patient, male, aged 56, was found to have a small nodule on the left cheek for 3 years without any symptoms. Outpatient surgical resection. Biopsy specimens: spindle organization with a part of the skin, the skin a lung tumor, the size of 2cm * 2cm, elevated 0.5cm, see a volcano shaped central mass gap, with a few gray white loose, fine granular sphacelus, on both sides of skin is pale red and dark red lip uprift. Microscope: exogenous epidermal cell hyperplasia, obvious lip lip two central uplift, obvious keratosis, basal side of epidermal cell is flat, eosinophilic and hyaline degeneration, and obvious infiltration of inflammatory cells, showed lesions subsided; on the other side near the basal margin (and therefore unable to understand epithelial cell proliferation, a) surrounded keratin, focal epidermal growth activity, but the base is still intact, no invasion phenomenon. Pathological diagnosis: acanthosis. 18 months after the operation, the patient had a small nodular protuberance on the side of Yu Yuans incision. The biopsy showed that the epidermis of the local lesion was sunken to the dermis, the cavity was filled with keratinized substance, and the basal cells were infiltrating and growing. The keratin and some cell keratosis were seen, and the pathological mitotic figures were seen. Pathological diagnosis: kerati