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onthe ofMMP-2
ofinhaledbudesonide
Theeffect expression
rats
TIMP-2in tissueof fibrosis
and lung pulmonary
Abstract
ofinhaled the
theeffect
investigate
Objective:To
inhibitors
of tissue
ofmatix
expression
of tissueof
lung
metalloproteinases.2(TIMP一2)in
rat fibrosis,andtodiscussthe mechanism.
induced possible
pulmonary
intotheBud
were divided
Wistarrats randomly
Methods:Forty.five
theBLM
BLM andtheNS Bud and group
group
group,thegroup group.The
withBLMtoinduce fibrosis,while
were instilled pulmonary
intratracheally
Bud were
inthesamecondition.The
NS withNS group
the
group
onthe1-6th theothertwo with
aerosolizedwithBud day,while groups
the 4thand28th
ratsineach were killedon 7th,1
NS.Five group randomly
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