基于多变量趋势分析的心肌梗塞风险评估.docVIP

基于多变量趋势分析的心肌梗塞风险评估 王见荣，夏岚，梁妃学，郭劲松，邓亲恺 (510515 广州，南方医科大学基础医学院生物信息学研究室) 摘要: 目的 基于心血管疾病患者的心率变异性（Heart rate variability，HRV）、心率减速力（deceleration capacity，DC）以及脉搏波传导速度（Pulse wave velocity，PWV）等多变量的测量与分析，研究心肌梗塞风险早期评估的可行性。方法 随机选择35名心血管疾病患者(11例心肌梗塞、8例冠心病、6例动脉硬化和10例高血压)和31个正常对照组，采用自主研制的心肌梗塞风险评估平台，采集15分钟的心电数据和1分钟的脉搏波数据，进行HRV、DC、PWV分析，并与对照组结果进行比较；结果 心血管疾病组与对照组的HRV、DC和PWV分析结果具有明显的差异性，而其中DC和HRV时域分析方法中的NN50、PNN50及TINN还能有效反映出相关病理的渐变过程。结论 综合HRV、DC和PWV等参变量的趋势分析能够为心肌梗塞早期风险评估、临床筛查和预警提供参考。 [关键词] 心肌梗塞；心率变异性；心率减速力；脉搏波传导速度；无创检测 [中图法分类号] R318 Risk evaluation of myocardial infarction based on multivariate trend analysis Wang Jianrong, Xia Lan, Liang FeiXue, Guo JinSong, Deng QinKai (Lab of Bioinformatics, School of Basic Medical Science, Southern Medical University, Guangzhou 510515 , China) Abstract: Objective To study the feasibility of myocardial infarction risk assessment by noninvasive multivariable trend analysis, including HRV(heart rate variability), DC(deceleration capacity of heart rate) and PWV(pulse wave velocity). Methods Thirty five patients with cardiovascular disease (11 Myocardial infarction(MI), 8 coronary artery disease(CAD), 6 artery atherosclerosis(AA) and 10 hypertension) and 31 healthy subjects were randomly selected for this research; 15mins ECG and 1mins pulse wave data were collected Based on the analysis workbench developed by our Lab, HRV, DC and PWV between the cardiovascular group and the control group were analyzed and compared; Results the HRV indices, DC and PWV were significantly high in control group compared to cardiovascular group, especially the DC and the HRV indices including NN50, PNN50 and TINN. Conclusion the earlier risk for MI can be quantified by noninvasive multivariable trend analysis of HRV, DC and PWV. Key words: Myocardial infarction; HRV; DC; PWV; noninvasive detection Supported by the Science and Technology Planning Projects of Guangdong Province (2010A030500007，2011B010200009) dqk001@ 引言 心血管疾病(Cardiovascular Disease, CVD)是一种严重威胁人类健康的慢性