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comparison of methods for analysis of selective genotyping survival data比较的方法分析选择性基因分型的生存数据
Genet. Sel. Evol. 38 (2006) 637–655 637
c
INRA, EDP Sciences, 2006
DOI: 10.1051/gse:200626
Original article
Comparison of methods for analysis
of selective genotyping survival data
a b b
Joseph P. ME , Wuyan Z , Kenneth J. K ,
a a ∗
Susan J. L , Jack C.M. D
a Department of Animal Science and Center for Integrated Animal Genomics, Iowa State
University, Ames, USA
b Department of Statistics, Iowa State University, Ames, USA
(Received 23 August 2005; accepted 30 May 2006)
Abstract – Survival traits and selective genotyping datasets are typically not normally dis-
tributed, thus common models used to identify QTL may not be statistically appropriate for
their analysis. The objective of the present study was to compare models for identification of
QTL associated with survival traits, in particular when combined with selective genotyping.
Data were simulated to model the survival distribution of a population of chickens challenged
with Marek disease virus. Cox proportional hazards (CPH), linear regression (LR), and Weibull
models were compared for their appropriateness to analyze the data, ability to identify associa-
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