discovery of active enhancers through bidirectional expression of short transcripts发现活性增强剂通过双向的表达简短的记录.pdfVIP

Melgar et al. Genome Biology 2011, 12:R113 /2012/12/11/R113 RESEARCH Open Access Discovery of active enhancers through bidirectional expression of short transcripts Michael F Melgar1,2, Francis S Collins1* and Praveen Sethupathy3,4,5* Abstract Background: Long-range regulatory elements, such as enhancers, exert substantial control over tissue-specific gene expression patterns. Genome-wide discovery of functional enhancers in different cell types is important for our