dual role of autophagy in hiv-1 replication and pathogenesis自噬在hiv - 1复制和发病机制的双重作用.pdfVIP

Killian AIDS Research and Therapy 2012, 9:16 /content/9/1/16 REVIEW Open Access Dual role of autophagy in HIV-1 replication and pathogenesis M Scott Killian Abstract Autophagy, the major mechanism for degrading long-lived intracellular proteins and organelles, is essential for eukaryotic cell homeostasis. Autophagy also defends the cell against invasion by microorganisms and has important roles in innate and adaptive immunity. Increasingly evident is that HIV-1 repl