原创力文档angiotensin-i-converting enzyme (ace) inhibitors from marine resources prospects in the pharmaceutical industry从海洋资源angiotensin-i-converting酶(ace)抑制剂在制药行业的前景.pdfVIP
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angiotensin-i-converting enzyme (ace) inhibitors from marine resources prospects in the pharmaceutical industry从海洋资源angiotensin-i-converting酶(ace)抑制剂在制药行业的前景
Mar. Drugs 2010, 8, 1080-1093; doi:10.3390/md8041080
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Review
Angiotensin-I-Converting Enzyme (ACE) Inhibitors from
Marine Resources: Prospects in the Pharmaceutical Industry
Isuru Wijesekara 1 and Se-Kwon Kim 1,2,*
1 Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan
608-737, Korea; E-Mail: isurumatara@ (I.W.)
2 Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Korea
* Author to whom correspondence should be addressed; E-Mail: sknkim@pknu.ac.kr;
Tel.: +82-51-629-7094; Fax: +82-51-629-7099.
Received: 19 February 2010, in revised form: 8 March 2010 / Accepted: 29 March 2010 /
Published: 31 March 2010
Abstract: Hypertension or high blood pressure is one of the major independent risk factors
for cardiovascular diseases. Angiotensin-I-converting enzyme (EC ; ACE) plays an
important physiological role in regulation of blood pressure by converting angiotensin I to
angiotensin II, a potent vasoconstrictor. Therefore, the inhibition of ACE activity is a
major target in the prevention of hypertension. Recently, the search for natural ACE
inhibitors as alternatives to synthetic drugs is of great interest to prevent several side
effects and a number of novel compounds such as bioactive peptides, chitooligosaccharide
derivatives (COS) and phlorotannins have been derived from marine organisms as potential
ACE inhibitors. These inhibitory
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