anti-parasitic compounds from streptomyces sp. strains isolated from mediterranean sponges从链霉菌属sp寄生虫化合物。从地中海海绵分离.pdfVIP

Mar. Drugs 2010, 8, 373-380; doi:10.3390/md8020373 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Communication Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges Sheila Marie Pimentel-Elardo 1,2,*, Svitlana Kozytska 2, Tim S. Bugni 3,†, Chris M. Ireland 3, Heidrun Moll 2 and Ute Hentschel 1,2 1 Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs Platz 3, 97082 Würzburg, Germany 2 Research Center for Infectious Diseases, Josef-Schneider-Straße 2, 97080 Würzburg, Germany 3 Department of Medicinal Chemistry, University of Utah, Salt Lake City, 84112 Utah, USA † Present address: School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA. * Author to whom correspondence should be addressed; E-Mail: sheila-marie.elardo@mail.uni- wuerzburg.de; Tel.: 0049-931-31-86039; Fax: 0049-931-31-86235. Received: 26 December 2009; in revised form: 2 February 2010 / Accepted: 4 February 2010 / Published: 23 February 2010 Abstract:  Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic