antiviral activity of baicalein and quercetin against the japanese encephalitis virus黄芩甙元的抗病毒活性和槲皮素对日本脑炎病毒.pdfVIP

Int. J. Mol. Sci. 2012, 13, 16785-16795; doi:10.3390/ijms131216785 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Antiviral Activity of Baicalein and Quercetin against the Japanese Encephalitis Virus Jefree Johari 1, Aynaz Kianmehr 1, Mohd Rais Mustafa 2, Sazaly Abubakar 1 and Keivan Zandi 1,* 1 Tropical Infectious Disease Research and Education Center (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: jefree.johari@.my (J.J.); aynaz99@ (A.K.); sazaly@.my (S.A.) 2 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: rais@.my * Author to whom correspondence should be addressed; E-Mail: keivan@.my; Tel./Fax: +603-7967-5757. Received: 28 September 2012; in revised form: 7 November 2012 / Accepted: 8 November 2012 / Published: 7 December 2012 Abstract: Japanese encephalitis (JE), a mosquito-borne viral disease, is endemic to the entire east and southeast Asia, and some other parts of the world. Currently, there is no effective therapeutic available for JE; therefore, finding the effective antiviral agent against JEV replication is crucial. In the present study, the in vitro antiviral activity of baicalein and quercetin, two purportedly antiviral bioflavonoids, was evaluated against Japanese encephalitis virus (JEV) replicat