5第五章 补体系统的.pptVIP

第五章 补体系统  (complement system) ;第一节 补体概述;羊抗血清+霍乱弧菌;（一）补体系统的组成;经典激活途径 C1q、C1r、C1s、C2、C4 旁路激活途径 B因子、D因子、备解素（P因子） 甘露糖结合凝集素激活途径（MBL途径） MBL、MBL相关丝氨酸蛋白酶 ;补体调节蛋白;;（三）补体的生物合成;第二节 补体系统的激活;补体激活的三条途径;（一） 经典激活途径（classical pathway）;;a. 抗原抗体结合，Ig的 Fc段空间构型改变，易与补体C1q结合。;经典途径活化过程;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;（二）旁路激活途径（alternative pathway）;旁路途径活化过程;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;（三） MBL途径;MBL途径活化过程;补体活化的共同末端效应——细胞裂解;MAC组分;C5的活化;MAC的形成;MAC插入细胞膜;打孔！;MAC破坏包膜病毒的包膜;三条激活途径的比较;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;（一）经典途径的调节;;DAF 对C3活化的抑制作用;DAF 对C3 活化的调节;（二）旁路途径的调节;Autologous cell membrane;（三）膜攻击复合物形成的调节;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;补体受体（complement receptor, CR）;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;★ 第四节　补体的生物学作用;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;（二）补体的病理生理学意义;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;第五节 补体系统与疾病;陈发性夜间血红蛋白尿;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;补??缺陷的临床表现; C1IHN缺陷引起遗传性血管神经性水肿，属常染色体显性遗传病。;小 结