猪繁殖与呼吸道症候群.PDF

猪繁殖與呼吸道症候群 Porcine reproductive and respiratory syndrome (PRRS) 台灣百靈佳殷格翰股份有限公司 動物用藥處 游建和 ABCD 歷史 • 1986/87 first described in North America: “mystery swine disease” • 1990 detected in Europe (Germany) and then spread across the rest of Europe. • 1991 the virus was isolated in Lelystad, the Netherlands and in Minnesota, USA • 1993 detected in Taiwan • 1994/ 1996 Boehringer Ingelheim launched first vaccine in collaboration with Lelystad and Minnesota • 1996 PRRSV reported in China • 2000 Highly pathogenic PRRS 184 strain, MN, USA • 2006 Highly pathogenic PRRS in China • 2007 Highly pathogenic 1-18-2 in Iowa and Minnesota, USA ABCD PRRS • 90年代初期”神秘猪病”. • 特徵在母猪為晚期流產, 生出弱小猪,或死產 . • 在保育猪或肥育猪為呼吸道症狀. • 近來出現毒力更強的毒株 (i.e.高熱病 ). ABCD PRRS • Genotype 1 • Prototype: Lelystad virus predominating Europe • Genotype 2 • North America and Asia A variant of genotype 2 is the cause of porcine high fever disease (PHFD) in Asia • Countries free of PRRS: Australia, New Zealand, Brazil, Finland, Norway, Sweden and Switzerland ABCD PRRS 病毒特性 • 分類: Family 科( ): Arteriviridae Genus 屬( ): Arterivirus • 在肺泡巨噬細胞中增殖 • 長的病毒血症期 • 次臨床持續感染(200 days) • 不同分離株毒力變異大 ABCD PRRS Virus: ORF 1a 2 4 6 1b 3 5 7 RNA