LD50半数致死剂量.pdfVIP

Environment, Health and Safety Committee [EHSC] Note On “ LD50 ” [ LETHAL DOSE 50% ] This Note is designed to provide guidance to RSC members, though it This Note was produced by may also be useful to others with a particular interest in the subject. It a Working Party of the Environment, Health and is an update of the original version which was issued in 1996. Safety Committee [EHSC] of the Royal Society of The LD50 test and its variants were often undertaken as a result of Chemistry with expert legislative requirements. These tests are now considered obsolete input from the Society’s and nowadays they would rarely if ever be performed in the United Occupational and Kingdom and many other countries. Internationally accepted Environmental Toxicology Group. alternative tests have been developed. These use fewer animals and “absence of evident toxicity”, rather than death, as their criterion. They The Society is a registered have been accepted by most regulators as valid alternatives to LD50 Charity. Its Royal Charter testing. obliges it to serve the public interest by acting in an