a selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyadp-ribose polymerase inhibitors选择性消灭人类乳腺癌细胞nonhereditary phenanthridine-derived polyadp-ribose聚合酶抑制剂.pdfVIP

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a selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyadp-ribose polymerase inhibitors选择性消灭人类乳腺癌细胞nonhereditary phenanthridine-derived polyadp-ribose聚合酶抑制剂.pdf

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a selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyadp-ribose polymerase inhibitors选择性消灭人类乳腺癌细胞nonhereditary phenanthridine-derived polyadp-ribose聚合酶抑制剂

Available online /content/11/6/R78 Vol 11 No 6 Open Access Research article A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors 1 2 1 1 3 Dana Inbar-Rozensal , Asher Castiel , Leonid Visochek , David Castel , Françoise Dantzer , Shai Izraeli2 and Malka Cohen-Armon1 1The Neufeld Cardiac Research Institute and Dept. of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel 2Cancer Research Institute, Sheba Medical Center, Tel-Hashomer, Ramat-Gan 52621, Israel 3Laboratory of Molecular and Structural Biology, Ecole Superieure de Biotechnologie de Strasbourg, F-67400, Illkrich-Graffenstaden, France Corresponding author: Malka Cohen-Armon, marmon@post.tau.ac.il Received: 19 Feb 2009 Revisions requested: 6 Apr 2009 Revisions received: 28 Jul 2009 Published: 9 Nov 2009 Breast Cancer Research 2009, 11:R78 (doi:10.1186/bcr2445) This article is online at: /content/11/6/R78 © 2009 Inbar-Rozensal; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. Abstract Introduction PARP-1 (polyADP-ribose polymerase-1) is known epithelial cells MCF10A and mouse embryonic fibroblasts) and to be activated in response to DNA damage, and activated human breast cancer cells MCF-7 and MDA231. However, PARP-1 promotes DNA repair. However, a recently dis