a simple method for assessing sample sizes in microarray experiments一个简单的方法来评估微阵列实验的样本大小.pdfVIP

下载本文档

0
0
约4.36万字
约 6页
2017-10-14 发布于上海
举报
版权申诉

a simple method for assessing sample sizes in microarray experiments一个简单的方法来评估微阵列实验的样本大小.pdf

1、本文档共6页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

a simple method for assessing sample sizes in microarray experiments一个简单的方法来评估微阵列实验的样本大小

BMC Bioinformatics BioMed Central Methodology article Open Access A simple method for assessing sample sizes in microarray experiments Robert Tibshirani* Address: Health Research Policy, Stanford University, Stanford, CA 94305, USA Email: Robert Tibshirani* - tibs@ * Corresponding author Published: 02 March 2006 Received: 04 October 2005 Accepted: 02 March 2006 BMC Bioinformatics2006, 7:106 doi:10.1186/1471-2105-7-106 This article is available from: /1471-2105/7/106 © 2006Tibshirani; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: In this short article, we discuss a simple method for assessing sample size requirements in microarray experiments. Results: Our method starts with the output from a permutation-based analysis for a set of pilot data, e.g. from the SAM package. Then for a given hypothesized mean difference and various samples sizes, we estimate the false discovery rate and false negative rate of a list of genes; these are also interpretable as per gene power and type I error. We also discuss application of our method to other kinds of response variables, for example survival outcomes. Conclusion: Our method seems to be usefu