a simple method for assessing sample sizes in microarray experiments一个简单的方法来评估微阵列实验的样本大小.pdfVIP
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a simple method for assessing sample sizes in microarray experiments一个简单的方法来评估微阵列实验的样本大小
BMC Bioinformatics BioMed Central
Methodology article Open Access
A simple method for assessing sample sizes in microarray
experiments
Robert Tibshirani*
Address: Health Research Policy, Stanford University, Stanford, CA 94305, USA
Email: Robert Tibshirani* - tibs@
* Corresponding author
Published: 02 March 2006 Received: 04 October 2005
Accepted: 02 March 2006
BMC Bioinformatics2006, 7:106 doi:10.1186/1471-2105-7-106
This article is available from: /1471-2105/7/106
© 2006Tibshirani; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In this short article, we discuss a simple method for assessing sample size
requirements in microarray experiments.
Results: Our method starts with the output from a permutation-based analysis for a set of pilot
data, e.g. from the SAM package. Then for a given hypothesized mean difference and various
samples sizes, we estimate the false discovery rate and false negative rate of a list of genes; these
are also interpretable as per gene power and type I error. We also discuss application of our
method to other kinds of response variables, for example survival outcomes.
Conclusion: Our method seems to be usefu
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