原创力文档adjuvant glycerol is not beneficial in experimental pneumococcal meningitis辅助甘油不是有益的实验肺炎球菌脑膜炎.pdfVIP
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adjuvant glycerol is not beneficial in experimental pneumococcal meningitis辅助甘油不是有益的实验肺炎球菌脑膜炎
Blaser et al. BMC Infectious Diseases 2010, 10:84
/1471-2334/10/84
R E S E A R C H A R T I C L E Open Access
Research article
Adjuvant glycerol is not beneficial in experimental
pneumococcal meningitis
1,5 2,5 1,5 1,5 3,5 4
Cornelia Blaser , Matthias Klein , Denis Grandgirard , Matthias Wittwer , Heikki Peltola , Michael Weigand ,
Uwe Koedel2,5 and Stephen L Leib* 1,5
Abstract
Background: Bacterial meningitis in children causes high rates of mortality and morbidity. In a recent clinical trial, oral
glycerol significantly reduced severe neurological sequelae in paediatric meningitis caused by Haemophilus influenzae
type b, and a tendency towards a benefit of adjunctive glycerol was seen in pneumococcal meningitis.
Methods: Here we examined the effects of glycerol in pneumococcal meningitis of infant rats and adult mice. All
animals received ceftriaxone, and glycerol or placebo. Brain damage, hearing loss, and inflammatory parameters were
assessed.
Results: Clinically and by histopathology, animals treated with glycerol or placebo did not differ. While both groups
showed equally high levels of matrix metalloproteinase-9 at 24 h after infection, a significant difference in favour of
glycerol was observed at 40 h after infection. However, this difference in matrix metalloproteinase-9 in late disease did
not result in an improvement of histopathologic parameters.
Conclusion: No benefit of adjunctive glycerol was found in these models of pneumococcal meningitis.
Background cidate the pros and cons of GLY in PM [2,3]. Here we
The outcome of pneumococcal meningitis (PM) in chil-
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