原创力文档antioxidant rich flavonoids from oreocnide integrifolia enhance glucose uptake and insulin secretion and protects pancreatic β-cells from streptozotocin insult富含抗氧化剂类黄酮从oreocnide integrifolia增强葡萄糖摄取和胰岛素分泌和保护胰腺β-cells链脲霉素的侮辱.pdfVIP
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antioxidant rich flavonoids from oreocnide integrifolia enhance glucose uptake and insulin secretion and protects pancreatic β-cells from streptozotocin insult富含抗氧化剂类黄酮从oreocnide integrifolia增强葡萄糖摄取和胰岛素分泌和保护胰腺β-cells链脲霉素的侮辱
Ansarullah et al. BMC Complementary and Alternative Medicine 2011, 11:126
/1472-6882/11/126
RESEARCH ARTICLE Open Access
Antioxidant rich flavonoids from Oreocnide
integrifolia enhance glucose uptake and insulin
secretion and protects pancreatic b-cells from
streptozotocin insult
1 1 2 2 2
Ansarullah , Bhavna Bharucha , Mitesh Dwivedi , Naresh C Laddha , Rasheedunnisa Begum ,
Anandwardhan A Hardikar3 and AV Ramachandran1*
Abstract
Background: Insulin deficiency is the prime basis of all diabetic manifestations and agents that can bring about
insulin secretion would be of pivotal significance for cure of diabetes. To test this hypothesis, we carried out
bioactivity guided fractionation of Oreocnide integrifolia (Urticaceae); a folklore plant consumed for ameliorating
diabetic symptoms using experimental models.
Methods: We carried out bioassay guided fractionation using RINmF and C2C12 cell line for glucose stimulated
insulin secretion (GSIS) and glucose uptake potential of fractions. Further, the bioactive fraction was challenged for
its GSIS in cultured mouse islets with basal (4.5 mM) and stimulated (16.7 mM) levels of glucose concentrations.
The Flavonoid rich fraction (FRF) was exposed to 2 mM streptozotocin stress and the anti-ROS/RNS potential was
evaluated. Additionally, the bioactive fraction was assessed for its antidiabetic and anti-apoptotic property in-vivo
using multidose streptozotocin induced diabetes in BALB/c mice.
Results: The results suggested FRF to be the most active fraction as assessed by GSIS in RINm5F cells and its
ability for glucose uptake in C2C12 cells. FRF displayed significant potential in terms of increasing intracellular
calcium and cAMP levels even in presence of a phosphodiest
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