assessment of full field digital mammography (ffdm) detected microcalcification is not hindered by low spatial resolution评估全领域的数字乳房x光检查(ffdm)发现钙化灶不阻碍低空间分辨率.pdfVIP

Available online /supplements/4/S1 Abstracts from Symposium Mammographicum 2002 University of York, 17–19 July 2002 1 Molecular pathology of breast cancer SR Lakhani The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research The Royal Marsden Hospital, London, UK The multistep model of carcinogenesis in the breast suggests a ago, scientists studied disease initiation and progression in a transition from normal epithelium to invasive carcinoma via linear fashion, identifying and examining one cancer-related non-atypical and atypical hyperplasia and in situ carcinoma. molecule at a time. The recent development of technologies The introduction of mammographic screening has led to the that allow a large number of genes and gene products to be increased detection of preinvasive disease, and this has high- analysed simultaneously has brought renewed interest to lighted deficiencies in the biology and classification of such breast cancer research, with the hope of identifying a unique lesions. The excitement surrounding the development of DNA ‘fingerprint’ for each tumour and hence individualised treat- microarray analysis and proteomics has raised expectations ment. To date, histopathological assessment has been at the about the role of these techniques in understanding the biology heart of clinical management – does the new technology herald and translating these data to clinical practice. Only a few years the end? 2 Hormone replacement therapy (HRT): indications and side effects