phosida (phosphorylation site database) management, structural and evolutionary investigation, and prediction of phosphositesphosida(磷酸化网站数据库)管理、结构和演化的调查,和phosphosites的预测.pdfVIP

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phosida (phosphorylation site database) management, structural and evolutionary investigation, and prediction of phosphositesphosida(磷酸化网站数据库)管理、结构和演化的调查,和phosphosites的预测.pdf

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phosida (phosphorylation site database) management, structural and evolutionary investigation, and prediction of phosphositesphosida(磷酸化网站数据库)管理、结构和演化的调查,和phosphosites的预测

Volume 8, Issue 11, Article R250et al.Gnad2007 Open Access Software PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites Florian Gnad, Shubin Ren, Juergen Cox, Jesper V Olsen, Boris Macek, Mario Oroshi and Matthias Mann Address: Department for Proteomics and Signal Transduction, Max-Planck Institute for Biochemistry, Am Klopferspitz, D-82152 Martinsried, Germany. Correspondence: Matthias Mann. Email: mmann@biochem.mpg.de Published: 26 November 2007 Received: 29 June 2007 Revised: 8 August 2007 Genome Biology 2007, 8:R250 (doi:10.1186/gb-2007-8-11-r250) Accepted: 26 November 2007 The electronic version of this article is the complete one and can be found online at /2007/8/11/R250 © 2007 Gnad et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Phosphorylation site databasepPHOSIDA, a phosphorylation site database, integrates thousands of phosphosites identified by proteomics in various species./p Abstract PHOSIDA , a phosphorylation site database, integrates thousands of high- confidence in vivo phosphosites identified by mass spectrometry-based proteomics in various species. For each phosphosite, PHOSIDA lists matching kinase motifs, predicted secondary structures, conservation patterns, and its dynamic regulation upon stimulus. Using suppor