predictors of mortality among hiv infected patients taking antiretroviral treatment in ethiopia a retrospective cohort study预测死亡率艾滋病毒感染者服用抗逆转录病毒治疗在埃塞俄比亚回顾性队列研究.pdfVIP

Biadgilign et al. AIDS Research and Therapy 2012, 9:15 /content/9/1/15 RESEARCH Open Access Predictors of mortality among HIV infected patients taking antiretroviral treatment in Ethiopia: a retrospective cohort study 1 2* 3 Sibhatu Biadgilign , Ayalu A Reda and Tesfaye Digaffe Abstract Background: Studies indicate that there is high early mortality among patients starting antiretroviral treatment in sub-Saharan Africa. However, there is paucity of evidence on long term survival of patients on anti-retroviral treatment in the region. The objective of this study is to examine mortality and its predictors among a cohort of HIV infected patients on anti-retroviral treatment retrospectively followed for five years. Methods: A retrospective cohort study was conducted among HIV infected patients on ART in eastern Ethiopia. Cox regression and Kaplan-Meier analyses were performed to investigate factors that influence time to death and survival over time. Result: A total of 1540 study participants were included in the study. From the registered patients in the cohort, the outcome of patients as active, deceased, lost to follow up and transfer out was 1005 (67.2%), 86 (5.9%), 210 (14.0%) and 192 (12.8%) respectively. The overall mortality rate provides an incidence density of 2.03 deaths per 100 person years (95% CI 1.64 - 2.50). Out of a total of 86 deaths over 60 month period; 63 (73.3%) died during the first 12 months, 10 (11.6%) during the second year, and 10 (11.6%) in the third year of follow up. In multivariate analysis, the independent predictors for mortality were loss of more 10% weight loss, bedridden functional status at baseline, ≤ 200 CD4 cell count/ml, and advanced WHO stage patients. Conclusion: A lower level of mortality wa