preparation, characterization and efficacy evaluation of synthetic biocompatible polymers linking natural antioxidants制备、表征和有效性评价合成生物相容性聚合物链接天然抗氧化剂.pdfVIP

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preparation, characterization and efficacy evaluation of synthetic biocompatible polymers linking natural antioxidants制备、表征和有效性评价合成生物相容性聚合物链接天然抗氧化剂.pdf

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preparation, characterization and efficacy evaluation of synthetic biocompatible polymers linking natural antioxidants制备、表征和有效性评价合成生物相容性聚合物链接天然抗氧化剂

Molecules 2012, 17, 12734-12745; doi:10.3390/molecules171112734 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Preparation, Characterization and Efficacy Evaluation of Synthetic Biocompatible Polymers Linking Natural Antioxidants Sonia Trombino, Roberta Cassano *, Teresa Ferrarelli, Sonia Leta, Francesco Puoci and Nevio Picci Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende 87036, Cosenza, Italy * Author to whom correspondence should be addressed; E-Mail: roberta.cassano@unical.it; Tel./Fax: +39-984-493-227. Received: 13 July 2012; in revised form: 18 September 2012 / Accepted: 22 October 2012 / Published: 26 October 2012 Abstract: The purpose of this work was the synthesis, characterization and efficacy evaluation of new biocompatible antioxidant polymers linking trans-ferulic acid or -lipoic acid. In particular, ferulic or lipoic acid were introduced in the preformed polymeric backbone. The new antioxidant biopolymers were characterized by Fourier transform infrared spectroscopy and gel permeation chromatography. The degree of functionalization (moles of antioxidant per gram of polymer) was determined by the Gaur-Gupta method for free amino group determination and by the Folin method for the phenolic groups. Their ability to inhibit lipid peroxidation were estimated in rat liver microsomal membranes induced in vitro b